The Appetrol20 Program™
A six-week whole-food program, developed in clinical practice
Created by Marcelle Pick, OB/GYN Nurse Practitioner. Appetrol20 pairs homeopathic drops with a whole-food eating plan and weekly guidance to support healthy eating habits and mindful eating routines. No meal replacements. No calorie counting.
Includes a full 42-day supply of drops, the 21-Day QuickStart Guide, and six weeks of email guidance.
Marcelle Pick, OB/GYN Nurse Practitioner, developed this protocol after years of supporting women through midlife wellness challenges.
- 3,500+ Women completed the original program
- 2018 First offered in clinical practice
- 6 weeks Structured program length
- GMP Certified U.S. manufacturing
Based on outcomes from Marcelle Pick’s original 2018 “Drop 20 in 6” program, developed within her medical practice.
Marcelle has been featured on
- PBS
- Dr. Oz
- ABC
- FOX
- Glamour
- ELLE
- Woman's World
Appearances and features by Marcelle Pick. These outlets do not endorse the Appetrol20 Program.
Who this is for
Healthy eating habits can feel different in midlife
That's real, and there's support for it. Women in perimenopause and menopause often feel like nothing works the way it used to — and that is not a personal failure.
Appetrol20 is built for women 40+ who want structured lifestyle support rather than another round of restriction. Whole food rather than meal replacements. A six-week framework rather than an open-ended plan. Guidance every week rather than a guide you read once and put down.
If you have tried diet after diet and found nothing you could live with, this is a different shape of thing: a routine designed to fit an ordinary schedule and keep fitting it after the six weeks are over.
Whole-food consistency over extremes — a gentler approach to lasting habits.
The Appetrol20 approach
The six weeks
How the program works
A structured whole-food protocol across two three-week phases, with the drops and weekly guidance running alongside. No calorie counting. No meal replacements.
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Weeks 1–3 · The 21-Day QuickStart
The Appetrol20 21-Day QuickStart Guide walks you through the first phase of the program: whole food, real food, and no meal replacements. Everything comes from an ordinary grocery store.
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Weeks 4–6 · The second phase
You carry the same whole-food protocol into the second three-week phase, with the structure and the weekly guidance continuing throughout.
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Throughout · Appetrol20 drops
Two bottles cover the full 42 days, one per three-week phase. Appetrol20 drops are a homeopathic drug — not a dietary supplement — containing ingredients listed in the Homeopathic Pharmacopeia of the United States, manufactured in the USA in a nationally recognized homeopathic specialty facility following Good Manufacturing Practices.
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Every week · Guidance from Marcelle
Weekly email guidance from Marcelle Pick, OB/GYN Nurse Practitioner, supporting your routine through all six weeks of the program.
A typical week
What a week actually looks like
Two things run every day. One arrives once a week. That is the whole shape of it.
Take the drops as directed on the product label. The 21-Day QuickStart Guide sets out the first phase of the eating plan in detail. No calorie counting and no meal replacements at any point.
What arrives
What's included
One order. Everything needed for the full six weeks.
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2 bottles of Appetrol20 drops
A full 42-day supply — one bottle per three-week phase. A homeopathic drug containing HPUS-listed ingredients. No stimulants. No HCG.
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The 21-Day QuickStart Guide
Your guide to the first phase of the program: whole food, real food, no meal replacements.
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Six weeks of email guidance
Weekly emails from Marcelle Pick, OB/GYN Nurse Practitioner, to support your routine through all six weeks.
Who created the program
Marcelle Pick, OB/GYN Nurse Practitioner
Marcelle Pick developed the foundational framework of the Appetrol20 Program within her clinical practice, after years of supporting women through midlife wellness challenges. She co-founded the Women to Women Healthcare Center in Falmouth, Maine, in 1983, and was among the first practitioners in the country to be certified in Functional Medicine.
Certified OB/GYN Nurse Practitioner and Pediatric Nurse Practitioner
Faculty, Institute of Functional Medicine — among the first practitioners in the United States certified in Functional Medicine
MS in Nursing, Boston College–Harvard Medical School. BS in Nursing and BA in Psychology, University of New Hampshire
Co-founder, Women to Women Healthcare Center, Falmouth, Maine, 1983
Author of The Core Balance Diet, Is It Me or My Adrenals? and Is It Me or My Hormones?
Featured on Dr. Oz, FOX and ABC, and in Glamour, ELLE and Women's World. Her PBS special Is It Me or My Hormones? reached viewers nationwide
A message from Marcelle
Why I built this the way I did
If you have been looking for an approach to eating that you can actually live with, I understand. I spent years in my clinical practice — and in my own life — looking for something structured and sustainable rather than another round of restriction.
What I kept coming back to was real food, a clear framework, and somebody checking in each week. That combination became the program I ran in my practice, and it is the framework the Appetrol20 Program is built on. I am glad to be able to bring it to you directly.
— Marcelle Pick, OB/GYN Nurse Practitioner
Real food, a clear framework, and somebody checking in each week.
Marcelle Pick, OB/GYN NP
Participant experiences
From women who completed the original program
These accounts come from participants in Marcelle Pick's original program, shared with their consent.
Before and after. Individual results vary.
I feel healthy and educated about my body.
I had been continually gaining a few pounds every year for the last few years, no matter how little I ate or how much I exercised. I liked the fact that I was going to be eating real whole foods and retraining my body to know what foods actually work to help me maintain my health. One of the many other deciding factors was all of the extra support there was throughout the program. It really helped knowing there were others having the same experiences as me. I reached my goal and almost a month later I have maintained it.
Before and after. Individual results vary.
The only program I've been able to follow and see lasting results.
This program has enabled me to regain my self-esteem and begin living the healthy lifestyle I have always wanted. Before joining this program I had tried everything to find a program I could live with forever. I have lost over 30 lbs and now enjoy eating healthy meals.
Before and after. Individual results vary.
So well-rounded — it covered every aspect of my wellness.
I have lost 36 lbs, 21 inches, and a whole lot of puffiness. I gained confidence that I can continue to live this way. I have come such a long way, not only physically, but emotionally as well.
Based on outcomes from Marcelle Pick’s original 2018 “Drop 20 in 6” program, developed within her medical practice. Individual results vary. Results depend on many factors including age, genetics, activity level, and program adherence. No specific results are guaranteed.
Start the program
The 6-Week Appetrol20 Program
Everything needed for the full six weeks, in one order. Shipped to you, with the weekly guidance beginning as soon as you start.
$297 one-time
2 bottles of Appetrol20 homeopathic drops — full 42-day supply
The Appetrol20 21-Day QuickStart Guide
Six weeks of weekly email guidance from Marcelle Pick, OB/GYN NP
No meal replacements, shakes or proprietary foods required
Questions before you start? Get in touch.
Questions
Frequently asked questions
If something isn't covered here, ask us before you order.
What is the Appetrol20 Program?
The Appetrol20 Program is a six-week whole-food wellness program created by Marcelle Pick, OB/GYN Nurse Practitioner. It combines Appetrol20 homeopathic drops, a whole-food eating plan set out in the 21-Day QuickStart Guide, and six weeks of weekly email guidance. It is built around real food from an ordinary grocery store, with no meal replacements and no calorie counting, and is designed to support healthy eating habits and mindful eating routines.
Who is the Appetrol20 Program for?
It is designed for women 40+, including women in perimenopause and menopause, who are looking for structured lifestyle support and whole-food consistency rather than a restrictive diet. It suits women rebuilding consistency with food habits and those who want a defined six-week framework that fits an ordinary schedule.
Are Appetrol20 drops a dietary supplement?
No. Appetrol20 drops are a homeopathic drug, not a dietary supplement. The product is registered with the FDA and contains ingredients listed in the Homeopathic Pharmacopeia of the United States (HPUS). It is worth being precise about this: the FDA does not approve homeopathic drugs or dietary supplements, so no product in this category is FDA-approved. Registration and approval are different things.
Where are the drops made, and what is in them?
They are manufactured in the USA in a nationally recognized homeopathic specialty facility that follows Good Manufacturing Practices (GMP). The formulation contains ingredients listed in the Homeopathic Pharmacopeia of the United States. The drops contain no stimulants and no HCG.
Do the drops cause side effects?
Appetrol20 drops are a homeopathic drug, used at the very small ingredient concentrations characteristic of homeopathic preparations. We cannot tell you how you personally will respond to any product. If you are pregnant, nursing, have a medical condition, are taking prescription or over-the-counter medications, or have a history of eating disorders, talk to your healthcare provider before use.
Are there special foods, shakes or meal replacements I have to buy?
No. The program gives you a list of foods to choose from that you would buy at your local grocery store. There are no meal replacements, shakes or proprietary foods required, and no special equipment.
Is the program hard to follow, and does it take a long time to cook?
The program is structured to be straightforward. The 21-Day QuickStart Guide sets out the first phase clearly, and weekly emails from Marcelle carry you through all six weeks. Meals are built around simple whole foods you can prepare without special equipment or lengthy cooking.
Are the drops required, or can I do the program without them?
The 6-Week Program is sold and designed as a complete package — the drops, the eating plan and the weekly guidance together. The drops are a core component of the protocol as it was developed in Marcelle Pick's clinical practice, and the program is not offered without them.
How is Appetrol20 related to the original Drop 20 in 6 program?
Appetrol20 is built from the same foundational whole-food wellness framework as Marcelle Pick's original 2018 Drop 20 in 6 program, which was developed within her medical practice. The drops formulation and the nutritional framework are the same. What changed is delivery: the original program ran through individual appointments in her practice, while Appetrol20 delivers structured guidance by weekly email. Based on outcomes from Marcelle Pick's original 2018 Drop 20 in 6 program, developed within her medical practice. Individual results vary and no specific results are guaranteed.
What does it cost and what comes in the box?
The 6-Week Program is $297 and includes two bottles of Appetrol20 homeopathic drops (a full 42-day supply, one bottle per three-week phase), the Appetrol20 21-Day QuickStart Guide, and six weeks of weekly email guidance from Marcelle Pick, OB/GYN Nurse Practitioner.
What happens after the six weeks?
Participants who want to continue can enrol in the Appetrol20 Maintenance Plan, which continues the wellness routine with ongoing structured support.
From the wellness blog
Reading while you decide
Notes on whole-food eating, midlife wellness routines, and how the program is structured.
Why Eating Less Isn't Always the Answer After 40
A 2023 study of women aged 40 to 64 found that how you decide to eat may matter alongside how much. What the research actually shows,...
When the program ends: what makes an eating routine stick
Most structured eating plans work while you're on them. The more useful question is what's still standing six weeks after one ends — and why structure,...
After the six weeks
The Appetrol20 Maintenance Plan
Participants who complete the 6-Week Program and want to keep the routine going can continue with the Maintenance Plan and its ongoing structured support.